Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix.
Identifieur interne : 007929 ( Main/Exploration ); précédent : 007928; suivant : 007930Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix.
Auteurs : Rui-Cheng Ji [Japon]Source :
- Lymphatic research and biology [ 1539-6851 ] ; 2006.
Descripteurs français
- KwdFr :
- Acide hyaluronique (physiologie), Animaux, Endostatines (physiologie), Endothélium (physiologie), Humains, Interleukine-7 (physiologie), Intégrines (physiologie), Lymphangiogenèse (physiologie), Matrice extracellulaire (physiologie), Matrix metalloproteinases (physiologie), Molécules d'adhérence cellulaire neuronale (physiologie), Protéines de la matrice extracellulaire (physiologie), Protéines de tissu nerveux (physiologie), Serine endopeptidases (physiologie), Tissu lymphoïde (physiologie).
- MESH :
- physiologie : Acide hyaluronique, Endostatines, Endothélium, Interleukine-7, Intégrines, Lymphangiogenèse, Matrice extracellulaire, Matrix metalloproteinases, Molécules d'adhérence cellulaire neuronale, Protéines de la matrice extracellulaire, Protéines de tissu nerveux, Serine endopeptidases, Tissu lymphoïde.
- Animaux, Humains.
English descriptors
- KwdEn :
- Animals, Cell Adhesion Molecules, Neuronal (physiology), Endostatins (physiology), Endothelium (physiology), Extracellular Matrix (physiology), Extracellular Matrix Proteins (physiology), Humans, Hyaluronic Acid (physiology), Integrins (physiology), Interleukin-7 (physiology), Lymphangiogenesis (physiology), Lymphoid Tissue (physiology), Matrix Metalloproteinases (physiology), Nerve Tissue Proteins (physiology), Serine Endopeptidases (physiology).
- MESH :
- chemical , physiology : Cell Adhesion Molecules, Neuronal, Endostatins, Extracellular Matrix Proteins, Hyaluronic Acid, Integrins, Interleukin-7, Matrix Metalloproteinases, Nerve Tissue Proteins, Serine Endopeptidases.
- physiology : Endothelium, Extracellular Matrix, Lymphangiogenesis, Lymphoid Tissue.
- Animals, Humans.
Abstract
Exciting studies involving the molecular regulation of lymphangiogenesis in lymphatic-associated disorders (e.g., wound healing, lymphedema and tumor metastasis) have focused renewed attention on the intrinsic relationship between lymphatic endothelial cells (LECs) and extracellular matrix (ECM) microenvironment. ECM molecules and remodeling events play a key role in regulating lymphangiogenesis, and the "functionality"-relating molecules, especially hyaluronan, integrins, reelin, IL-7, and matrix metalloproteinases, provide the most fundamental and critical prerequisite for LEC growth, migration, tube formation, and survival, although lymphangiogenesis is directly or/and indirectly controlled by VEGF-C/-D/VEGFR- 3- Prox-1-, Syk/SLP76-, podoplanin/Ang-2/Nrp-2-, FOXC2-, and other signaling pathways in embryonic and pathological processes. New knowledge regarding the differentiation of initial lymphatics should enable improvements in understanding of a variety of cytokines, chemokines, and other factors. The lymphatic colocalization with histochemical staining by using the novel molecular markers (e.g., LYVE-1), along with subsequent injection technique with ferritin or some tracer, will reveal functional and structural features of newly formed and preexisting lymphatics. Growing recognition of the multiple functions of ECM and LEC molecules for important physiological and pathological events may be helpful in identifying the crucial changes in tissues subjected to lymph circulation and ultimately in the search for rational therapeutic approaches to prevent lymphatic-associated disorders.
DOI: 10.1089/lrb.2006.4.83
PubMed: 16808670
Affiliations:
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JI@med.oita-u.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anatomy, Biology and Medicine, Oita University Faculty of Medicine, Oita</wicri:regionArea><wicri:noRegion>Oita</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16808670</idno><idno type="pmid">16808670</idno><idno type="doi">10.1089/lrb.2006.4.83</idno><idno type="wicri:Area/PubMed/Corpus">003948</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003948</idno><idno type="wicri:Area/PubMed/Curation">003948</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003948</idno><idno type="wicri:Area/PubMed/Checkpoint">003948</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003948</idno><idno type="wicri:Area/Ncbi/Merge">002315</idno><idno type="wicri:Area/Ncbi/Curation">002315</idno><idno type="wicri:Area/Ncbi/Checkpoint">002315</idno><idno type="wicri:doubleKey">1539-6851:2006:Ji R:lymphatic:endothelial:cells</idno><idno type="wicri:Area/Main/Merge">007B10</idno><idno type="wicri:Area/Main/Curation">007929</idno><idno type="wicri:Area/Main/Exploration">007929</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix.</title><author><name sortKey="Ji, Rui Cheng" sort="Ji, Rui Cheng" uniqKey="Ji R" first="Rui-Cheng" last="Ji">Rui-Cheng Ji</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy, Biology and Medicine, Oita University Faculty of Medicine, Oita, Japan. JI@med.oita-u.ac.jp</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Anatomy, Biology and Medicine, Oita University Faculty of Medicine, Oita</wicri:regionArea><wicri:noRegion>Oita</wicri:noRegion></affiliation></author></analytic><series><title level="j">Lymphatic research and biology</title><idno type="ISSN">1539-6851</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Adhesion Molecules, Neuronal (physiology)</term><term>Endostatins (physiology)</term><term>Endothelium (physiology)</term><term>Extracellular Matrix (physiology)</term><term>Extracellular Matrix Proteins (physiology)</term><term>Humans</term><term>Hyaluronic Acid (physiology)</term><term>Integrins (physiology)</term><term>Interleukin-7 (physiology)</term><term>Lymphangiogenesis (physiology)</term><term>Lymphoid Tissue (physiology)</term><term>Matrix Metalloproteinases (physiology)</term><term>Nerve Tissue Proteins (physiology)</term><term>Serine Endopeptidases (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide hyaluronique (physiologie)</term><term>Animaux</term><term>Endostatines (physiologie)</term><term>Endothélium (physiologie)</term><term>Humains</term><term>Interleukine-7 (physiologie)</term><term>Intégrines (physiologie)</term><term>Lymphangiogenèse (physiologie)</term><term>Matrice extracellulaire (physiologie)</term><term>Matrix metalloproteinases (physiologie)</term><term>Molécules d'adhérence cellulaire neuronale (physiologie)</term><term>Protéines de la matrice extracellulaire (physiologie)</term><term>Protéines de tissu nerveux (physiologie)</term><term>Serine endopeptidases (physiologie)</term><term>Tissu lymphoïde (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Cell Adhesion Molecules, Neuronal</term><term>Endostatins</term><term>Extracellular Matrix Proteins</term><term>Hyaluronic Acid</term><term>Integrins</term><term>Interleukin-7</term><term>Matrix Metalloproteinases</term><term>Nerve Tissue Proteins</term><term>Serine Endopeptidases</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Acide hyaluronique</term><term>Endostatines</term><term>Endothélium</term><term>Interleukine-7</term><term>Intégrines</term><term>Lymphangiogenèse</term><term>Matrice extracellulaire</term><term>Matrix metalloproteinases</term><term>Molécules d'adhérence cellulaire neuronale</term><term>Protéines de la matrice extracellulaire</term><term>Protéines de tissu nerveux</term><term>Serine endopeptidases</term><term>Tissu lymphoïde</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Endothelium</term><term>Extracellular Matrix</term><term>Lymphangiogenesis</term><term>Lymphoid Tissue</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Exciting studies involving the molecular regulation of lymphangiogenesis in lymphatic-associated disorders (e.g., wound healing, lymphedema and tumor metastasis) have focused renewed attention on the intrinsic relationship between lymphatic endothelial cells (LECs) and extracellular matrix (ECM) microenvironment. ECM molecules and remodeling events play a key role in regulating lymphangiogenesis, and the "functionality"-relating molecules, especially hyaluronan, integrins, reelin, IL-7, and matrix metalloproteinases, provide the most fundamental and critical prerequisite for LEC growth, migration, tube formation, and survival, although lymphangiogenesis is directly or/and indirectly controlled by VEGF-C/-D/VEGFR- 3- Prox-1-, Syk/SLP76-, podoplanin/Ang-2/Nrp-2-, FOXC2-, and other signaling pathways in embryonic and pathological processes. New knowledge regarding the differentiation of initial lymphatics should enable improvements in understanding of a variety of cytokines, chemokines, and other factors. The lymphatic colocalization with histochemical staining by using the novel molecular markers (e.g., LYVE-1), along with subsequent injection technique with ferritin or some tracer, will reveal functional and structural features of newly formed and preexisting lymphatics. Growing recognition of the multiple functions of ECM and LEC molecules for important physiological and pathological events may be helpful in identifying the crucial changes in tissues subjected to lymph circulation and ultimately in the search for rational therapeutic approaches to prevent lymphatic-associated disorders.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Ji, Rui Cheng" sort="Ji, Rui Cheng" uniqKey="Ji R" first="Rui-Cheng" last="Ji">Rui-Cheng Ji</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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